Notts County pulled off a massive shock by beating top flight Sunderland at the Stadium of Light.
Craig Westcarr and Lee Hughes scored in either half to hand Paul Ince's
Lee Barnard and Guly were the heroes as Southampton
After a goalless first period, Barnard put the Saints ahead eight minutes after the interval and Guly climbed off the bench to complete the victory with two minutes remaining.
League Two Stevenage beat Newcastle 3-1 in the evening game to continue the FA Cup shocks.
A Mike Williamson own goal, Michael Bostwick and Peter Winn earned a famous victory for the hosts, while Joey Barton netted a consolation for the Magpies.
The Championship's Cardiff earned a draw at Premier League Stoke after Michael Chopra's
Jonathan Spector